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KMID : 1094020130300040296
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Journal of Veterinary Clinics
2013 Volume.30 No. 4 p.296 ~ p.300
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Immunohistochemical Diagnosis of Primary Renal Hemangiosarcoma in a Dog
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Jung Soo-Kyo
Kim Jae-Hoon
Yang Hyoung-Seok
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Abstract
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A 7-year-old castrated male Yorkshire Terrier was presented with a palpable intra-abdominal mass. In radiography, a large radioopaque renal mass and small abdominal mass were found on dorsal area of the abdomen. Grossly, red to brown color mass and a cystic structure (hydronephrosis) were embedded in the right kidney. Histopathologically, the mass had many irregular shaped neovascular channels lined by polygonal or oval shaped endothelial cells. These vessels and neoplastic cells had great invasive tendency to adjacent connective or fat tissues. Small abdominal mass had identical morphologic features as in renal mass. According to immunohistochemistry, the neoplastic cells in renal mass demonstrated strong positive signals for vimentin and CD31, and weak positive for von Willbrand factor. However, there were no positive reactions for cytokeratin. Based on the gross, histopathology and immunohistochemistry, this mass was diagnosed as primary renal hemangiosarcoma in a Yorkshire Terrier dog.
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KEYWORD
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CD31, dog, hemangiosarcoma, immunohistochemistry, kidney
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